解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-beta-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, inc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.06.021
更新日期:2010-07-30 00:00:00
abstract::In this issue of Molecular Cell, Roberts-Galbraith and colleagues report that a key cytokinetic regulator in fission yeast, Cdc15, is phosphorylated on numerous sites that collectively, but not individually, control its oligomerization state and its associations with the plasma membrane and interacting proteins. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.06.028
更新日期:2010-07-09 00:00:00
abstract::The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize ER-mitochondrial contact sites and monitor the localized [Ca(2+)] changes ([Ca(2+)](ER-mt)) using drug-inducible fluorescent interorg...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.06.029
更新日期:2010-07-09 00:00:00
abstract::A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent Piwi-interacting RNAs, associate with Argonaute family proteins to regulate gene expression in diverse cellular processes. These two species of small RNA have not been found in fungi. Here, by analyzing small RNAs associated with t...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.04.005
更新日期:2010-06-25 00:00:00
abstract::In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.06.015
更新日期:2010-06-25 00:00:00
abstract::Tumor progression shares many characteristics with the process of epithelial-to-mesenchymal transition (EMT). Cells that have undergone an EMT are known to have an increased resistance to apoptosis. CD95/Fas is an apoptosis-inducing receptor expressed on many tissues and tumor cells. During tumor progression CD95 is f...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.05.018
更新日期:2010-06-25 00:00:00
abstract::Polycomb proteins maintain cell identity by repressing the expression of developmental regulators specific for other cell types. Polycomb repressive complex-2 (PRC2) catalyzes trimethylation of histone H3 lysine-27 (H3K27me3). Although repressed, PRC2 targets are generally associated with the transcriptional initiatio...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.03.019
更新日期:2010-06-11 00:00:00
abstract::The SMN complex assembles Sm cores on snRNAs, a key step in the biogenesis of snRNPs, the spliceosome's major components. Here, using SMN complex inhibitors identified by high-throughput screening and a ribo-proteomic strategy on formaldehyde crosslinked RNPs, we dissected this pathway in cells. We show that protein s...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.03.014
更新日期:2010-05-28 00:00:00
abstract::The phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently deregulated in cancer. Downstream of PI3K, Akt1 and Akt2 have opposing roles in breast cancer invasive migration, leading to metastatic dissemination. Here, we identify palladin, an actin-associated protein, as an Akt1-specific substrate that mod...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.031
更新日期:2010-05-14 00:00:00
abstract::How polycomb group proteins repress gene expression in vivo is not known. While histone-modifying activities of the polycomb repressive complexes (PRCs) have been studied extensively, in vitro data have suggested a direct activity of the PRC1 complex in compacting chromatin. Here, we investigate higher-order chromatin...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.032
更新日期:2010-05-14 00:00:00
abstract::The molecular structures of crossover (CO) and noncrossover (NCO) intermediates were determined by sequencing the products formed when a gapped plasmid was repaired using a diverged chromosomal template. Analyses were done in the absence of mismatch repair (MMR) to allow efficient detection of strand-transfer intermed...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.028
更新日期:2010-04-23 00:00:00
abstract::X-linked mental retardation (XLMR) is an inherited disorder that mostly affects males and is caused by mutations in genes located on the X chromosome. Here, we show that the XLMR protein PHF8 and a C. elegans homolog F29B9.2 catalyze demethylation of di- and monomethylated lysine 9 of histone H3 (H3K9me2/me1). The PHD...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.03.002
更新日期:2010-04-23 00:00:00
abstract::Both splicing factors and microRNAs are important regulatory molecules that play key roles in posttranscriptional gene regulation. By miRNA deep sequencing, we identified 40 miRNAs that are differentially expressed upon ectopic overexpression of the splicing factor SF2/ASF. Here we show that SF2/ASF and one of its upr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.021
更新日期:2010-04-09 00:00:00
abstract::Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival. Here, we report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.015
更新日期:2010-03-26 00:00:00
abstract::The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger conformational changes in gp120 that allow the gp41 transmembrane envelope glycoprotein to mediate viral-cell membrane fusion? The transiti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.012
更新日期:2010-03-12 00:00:00
abstract::The disulfide relay system in the intermembrane space of mitochondria is of crucial importance for mitochondrial biogenesis. Major players in this pathway are the oxidoreductase Mia40 that oxidizes substrates and the sulfhydryl oxidase Erv1 that reoxidizes Mia40. To analyze in detail the mechanism of this oxidative pa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.01.017
更新日期:2010-02-26 00:00:00
abstract::B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we wi...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2010.01.025
更新日期:2010-02-12 00:00:00
abstract::A paradigm in transcriptional regulation is that graded increases in transcription factor (TF) concentration are translated into on/off transcriptional responses by cooperative TF binding to adjacent sites. Digital transcriptional responses underlie the definition of anatomical boundaries during development. Here we s...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.01.016
更新日期:2010-02-12 00:00:00
abstract::Innate immune responses are critical for the immediate protection against microbial infection. In Drosophila, infection leads to the rapid and robust production of antimicrobial peptides through two NF-kappaB signaling pathways-IMD and Toll. The IMD pathway is triggered by DAP-type peptidoglycan, common to most Gram-n...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.12.036
更新日期:2010-01-29 00:00:00
abstract::In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.12.028
更新日期:2010-01-15 00:00:00
abstract::Floral transition in plants is regulated by an integrated network of flowering genetic pathways. We show that an Arabidopsis PIN1-type parvulin 1, Pin1At, controls floral transition by accelerating cis/trans isomerization of the phosphorylated Ser/Thr-Pro motifs in two MADS-domain transcription factors, SUPPRESSOR OF ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.12.020
更新日期:2010-01-15 00:00:00
abstract::The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contain nontranslating mRNAs, translation initiation components, and many additional proteins affecting mRNA function. Stress gra...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2009.11.020
更新日期:2009-12-25 00:00:00
abstract::Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that need to be disrupted for membrane attachment and targeting of Rab proteins. The Legionella pneumophila protein DrrA displaces GDI from Rab1:GDI complexes, incorporating Rab1 into Legionella-containing vacuoles and activating...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.11.014
更新日期:2009-12-25 00:00:00
abstract::SOCS1 is lost in many human tumors, but its tumor suppression activities are not well understood. We report that SOCS1 is required for transcriptional activity, DNA binding, and serine 15 phosphorylation of p53 in the context of STAT5 signaling. In agreement, inactivation of SOCS1 disabled p53-dependent senescence in ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.044
更新日期:2009-12-11 00:00:00
abstract::Signal-transduction cascades are usually studied on cell averages, masking variability between individual cells. To address this, we studied in individual cells the dynamic response of ERK2, a well-characterized MAPK signaling protein, which enters the nucleus upon stimulation. Using fluorescent tagging at the endogen...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.11.025
更新日期:2009-12-11 00:00:00
abstract::Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elusive. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.040
更新日期:2009-11-25 00:00:00
abstract::Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, CLOCK and BMAL1. Current models posit that CRY is the dominant repressor, while PER may play an accessory role. In this stu...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.10.012
更新日期:2009-11-13 00:00:00
abstract::Budding yeast Cdc13, Stn1, and Ten1 form the CST complex to protect telomeres from lethal DNA degradation. It remains unknown whether similar complexes are conserved in higher eukaryotes or not. Here we isolated mammalian STN1 and TEN1 homologs and CTC1 (conserved telomere maintenance component 1). The three proteins ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.009
更新日期:2009-10-23 00:00:00
abstract::Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are incompletely understood. Here, we show that the oncogenic mutant of Flt3 (Flt3-ITD), when localized at the endoplasmic reticulum (ER), aberrantly activates STAT5 and...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.019
更新日期:2009-10-23 00:00:00
abstract::Polycomb group (PcG) proteins exert essential functions in the most disparate biological processes. The contribution of PcG proteins to cell commitment and differentiation relates to their ability to repress transcription of developmental regulators in embryonic stem (ES) cells and in committed cell lineages, includin...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.008
更新日期:2009-10-09 00:00:00
abstract::In this issue of Molecular Cell, Lee et al. (2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.09.002
更新日期:2009-09-24 00:00:00
abstract::To unravel the roles of LXRs in inflammation and immunity, we examined the function of LXRs in development of IFN-gamma-mediated inflammation using cultured rat brain astrocytes. LXR ligands inhibit neither STAT1 phosphorylation nor STAT1 translocation to the nucleus but, rather, inhibit STAT1 binding to promoters and...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.07.021
更新日期:2009-09-24 00:00:00
abstract::MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3'UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization. Here we examine the mechanism and kinetics of miRNA-mediated deadenylation in mouse Krebs-2 ascites extract. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.004
更新日期:2009-09-24 00:00:00
abstract::In this issue of Molecular Cell, Schmidt et al. (2009) untangle the interplay between the COP9 signalosome (CSN), cullin-associated and neddylation-dissociated 1 (CAND1) protein, and cullin-RING ubiquitin ligases (CRLs). ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.08.011
更新日期:2009-09-11 00:00:00
abstract::Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The X-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain we term the SP-CTD. Structure-based m...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.07.013
更新日期:2009-09-11 00:00:00
abstract::Brr2 is a unique DExD/H box protein required for catalytic activation and disassembly of the spliceosome. It contains two tandem helicase cassettes that both comprise dual RecA-like domains and a noncanonical Sec63 unit. The latter may bestow the enzyme with unique properties. We have determined crystal structures of ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.006
更新日期:2009-08-28 00:00:00
abstract::In this issue of Molecular Cell, Huang et al. (2009) describe two heterotrimeric single-stranded DNA binding complexes, SOSS1 and SOSS2, that function downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.07.016
更新日期:2009-08-14 00:00:00
abstract::Nucleosomes are surprisingly dynamic structures in vivo, showing transcription-independent exchange of histones H2A-H2B genome-wide and exchange of H3-H4 mainly within the promoters of transcribed genes. In addition, nucleosomes are disrupted in front of and reassembled behind the elongating RNA polymerase. Here we sh...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.07.001
更新日期:2009-08-14 00:00:00
abstract::A study in this issue of Molecular Cell (Elcheva et al., 2009) shows the inherent instability of the betaTrCP1 mRNA to be caused by microRNA-183 targeting the coding sequence; interestingly, this action is directly opposed by the RNA-binding protein CRD-BP. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.07.006
更新日期:2009-07-31 00:00:00
abstract::miRNAs are largely known to base pair with the 3'UTR of target mRNAs, downregulating their stability and translation. mRNA of betaTrCP1 ubiquitin ligase is very unstable, but unlike the majority of mRNAs where 3'UTR determines the rate of mRNA turnover, betaTrCP1 mRNA contains cis-acting destabilizing elements within ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.06.007
更新日期:2009-07-31 00:00:00